As the name suggests, motor neurone disease is a disease in which the neurones that control muscle function, the motor neurones, are dysfunctional and eventually die. This loss of motor neurones from the nervous system gives rise to the outward symptoms of loss of muscle control and wasting. However, motor neurones may not be the only dysfunctional cells that contribute to MND.

Just like flicking a light switch genes can be switched on and off by a process known as methylation. This is a useful thing in the body because there are genes that need to be switched on in liver cells that are not required in brain cells and vice versa.

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